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  Members Area

IMI | The Innovative Medicines Initiative
EFPIA | European Federation of Pharmaceutical Industries and Associations

Workpackage 05

Workpackage Objectives

  • Development of a new methodology for measuring endogenous serotonin and noradrenaline levels in human brain.
  • Application of the combined use of radioligand binding and functional imaging of transmitter levels for target validation.

Workpackage Leads

Academic Lead: Dr. Christer Halldin, Karolinska Institutet, Sweden
EFPIA Lead: Dr. Erik Wong, AstraZeneca AB, US

Workpackage Partners

  • H. Lundbeck A/S
  • Karolinska Institutet
  • AstraZeneca AB
  • GSK Company Ltd
  • Novartis Pharma AG
  • Orion Corporation
  • F. Hoffmann-La Roche AG

Synergy between academia and industry

This workpackage brings together the combined chemistry and biology resources of the European pharmaceutical industry as a tremendous asset when positioned in a collaborative fashion with academic centers having extensive experience in radioligand development. While such collaborations have previously only been attempted on a small scale across two partners NEWMEDs creates an opportunity for an open and extensive collaboration. Besides GSK, no European industry has access to the full range of expertise and technical equipment in a PET-center, hence a coordinated effort in the workpackage offer increased chance of success to overcome technical and biololgical challenges. The tasks outlined also provide numerous opportunities for cross-training/-learning between academia and industry and we anticipate a number of students, industry-scientists and post-doctoral fellows to be cross-trained in this workpackage.


WP05 - Cross-Species and Neurochemical Imaging (PET) methods for drug discovery